So—for the umpteenth time—why has this urgent information not been
publicized by CDC/Dr. Fauci/WHO, and reported by "our free press"? 
They scream at us non-stop to wear our masks and stay six feet apart, 
to "keep us safe," and yet say nothing about this?

MCM

Vitamin D Treatment Is Associated with Reduced Risk of Mortality in Patients with COVID-19: A Cross-Sectional Multi-Centre Observational Study

17 Pages Posted: 20 Oct 2020

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3690902

Stephanie Fenxi Ling

The University of Manchester

Eleanor Broad

Tameside and Glossop Integrated Care NHS Foundation Trust

Rebecca Murphy

Tameside and Glossop Integrated Care NHS Foundation Trust

Joseph Mundattuchundayil Pappachan

University of Manchester

Satveer Pardesi-Newton

University Hospitals of Leicester NHS Trust - Leicester Royal Infirmary

Marie-France Kong

University Hospitals of Leicester NHS Trust - Leicester General Hospital

Edward Bernard Jude

Tameside and Glossop Integrated Care NHS Foundation Trust

More...

Abstract

Background: The 2019 novel coronavirus disease (Covid-19) worldwide pandemic has posed the most substantial and severe public health issue for several generations, and therapeutic options for it have not yet been optimised. Vitamin D has been proposed in the pharmacological management of Covid-19 by various sources. This study aimed to determine whether Covid-19 disease outcomes were affected by vitamin D status, and to elucidate any predictors of Covid-19 outcomes.

Methods: Patients hospitalised with Covid-19 were opportunistically recruited from three different UK hospitals and their data were collected. Logistic regression was used to determine any relationships between vitamin D status and various predictors, including mortality and ventilation, and to determine any relationships between mortality, ventilation, and various predictors.

Findings: Vitamin D status was not associated with any outcomes of Covid-19 investigated, following adjustment for age and sex. However, treatment with vitamin D was significantly associated with a reduced risk of death, following adjustment for age and sex (ORadj 0·48, 95% CI 0·32 – 0·70, p = 1·79x10-4). This relationship remained significant when also adjusted for baseline vitamin D levels (ORadj 0·47, 95% CI 0·33 – 0·70, p = 1·27x10-4).

Interpretation: Treatment with vitamin D, regardless of baseline serum vitamin D levels, appears to be associated with a reduced risk of mortality in acute in-patients admitted with Covid-19. Further work on large population studies needs to be carried out to determine adequate serum levels of vitamin D, as well as multi-dose clinical trials of vitamin D treatment to assess maximum efficacy.

Trial Registration: The study was also registered on Clinicaltrials.gov (reference number NCT04386044), prior to commencement.

Funding: None.

Declaration of Interests: The authors have no conflicts of interest.

Ethics Approval Statement: Ethical approval was granted by the Health and Care Research Wales Research Ethics Committee (IRAS number 285337).

Keywords: COVID-19, SARS-CoV-2, 2019 novel coronavirus, severe acute respiratory syndrome coronavirus 2, vitamin D, cholecalciferol, 25-hydroxyvitamin D, mortality, death, invasive ventilation, intubation, endotrachel intubation, continuous positive airways pressure, CPAP

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